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KMID : 0894520040080020085
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Development & Reproduction
2004 Volume.8 No. 2 p.85 ~ p.89
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Effect of DEHP Administration on Reproduction in Pregnant Mice Ⅰ. Effect of DEHP Administration on Reproductive Characteristic and Blood Hematological Values in Pregnant Mice
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박동헌/Park DH
장현용/박춘근/정희태/김정익/양부근/Jang HY/Park CK/Cheong HT/Kim CI/Yang BK
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Abstract
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This study is illustrated that 1) the effects of DEHP administration on body weight, sex ratio and litter size on 19 days in the prenatal period 2) the effects of reproductive organ weight and blood hematological values on 25 days postpartum in pregnant mice. DEHP was administrated to pregnant mice by intraperitoneal injection at 0, 0.5, 1.0 and 10.0mg/kg B.W from day 1 to day 16 in the gestation period with 5 times at 3 days interval. There were no significantly differences in the material body weight, litter size and sex ratio on 19 days in the prenatal period. The body weight of the fatal male mice was slightly lower in 1.0 and 10.0mg DEHP groups than in any other groups. The reproductive organ weight and hematological values in dam mice on 25 days postpartum were not affected by DEHP administration. The histological evaluation of ovary in dam mice on 25 days after dilivery was not different in all experimental groups, but the endometriosis and edema of uterus in dam mice were significantly decreased in 0.5mg DEHP group than that of control group.These results indicate that the administration of low concentration of DEHP was not affected on reproductive characteristic and blood hematological values in pregnant mice.
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KEYWORD
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